The Science of Reading, 50 years of research on the critical elements of reading, directs us to provide systematic instruction on phonemic awareness, decoding, encoding, fluency, vocabulary, background knowledge, and comprehension. However, to optimize learning, we must draw from the Science of Instruction, providing engaging, explicit instruction lessons that are highly structured, utilizing the steps of “I do, we do, you do,” eliciting frequent student responses, monitoring student performance, and providing immediate feedback including praise and corrections. Both are Imperative!